La Posada's main building is located between two historic structures:
- The elegant Victorian A.M. Bruni residence later became the Laredo Telephone Exchange, served as a customs house, and is now home to the hotel's Tack Room Bar & Grill.
- The old San Agustin Convent now houses the San Agustin Ballroom and the George Washington's Birthday Association Museum, which honors Laredo's century old tradition of the Washington Birthday Celebration and was added to the property in 2000.
La Posada Hotel also has a second museum on its premises – the original 150-year old Capitol building of the Republic of the Rio Grande.
In 2007, La Posada underwent a complete $15 million makeover that celebrates the hotel's historic Spanish influence and colonial architecture. After nearly 50 years of service, La Posada Hotel still bustles with activity, playing host to countless entertainers, politicians and sports celebrities.